Selecting the right size reduction equipment for the pharmaceutical industry is far more than a technical decision—it’s a strategic investment in your operation’s efficiency, safety, and regulatory success. At The Mark‑Costello Co., we provide a wide range of reduction systems including shredders, grinders, granulators, and micronizing mills, each engineered to address the unique demands of pharmaceutical manufacturing environments. What makes our solutions stand apart is not just the quality of the build, but the understanding that pharmaceutical operations require unparalleled consistency, documentation, and scalability.
Our shredders and granulators are designed for the initial reduction of bulk pharmaceutical materials such as dry active ingredients, excipients, and raw crystal forms. These machines are capable of handling input materials in various formats and reducing them to particle sizes that are ideal for further processing or mixing. The granulators use carefully calibrated rotor blades and screen combinations to maintain tight particle size distributions while avoiding over-shearing or thermal degradation. When needed, integrated cooling systems and dust containment modules are available to support heat-sensitive compounds and prevent airborne contamination, particularly important when dealing with potent ingredients.
For applications that demand ultra-fine particle reduction—such as dry powder inhalers, parenteral drugs, or high-potency oncology medications—our fine impact mills and air jet mills offer the precision needed to deliver particles in the micron or even sub-micron range. These machines employ highly controlled air streams or impaction forces to reduce materials while maintaining the product’s chemical integrity. We design these systems with containment in mind, offering glove box compatibility, nitrogen inerting, and pressure-rated housings to maintain safety and control exposure. Moreover, all of our equipment is available with GMP-certified finishes and Clean-in-Place (CIP) capabilities, helping your facility remain compliant with even the most rigorous inspection standards.
But selecting the right machine isn’t just about meeting today’s goals—it’s about preparing for what’s next. The Mark‑Costello Co. offers scalable designs that support laboratory-scale R&D, pilot-scale formulation development, and full-scale commercial production. Modular setups make it easy to switch between processes, formulations, or batch sizes without disrupting facility operations. Each piece of equipment can be integrated with automated control systems, including SCADA interfaces and data logging tools, to support audit trails, process validation, and 21 CFR Part 11 compliance. With us, you’re not just purchasing equipment—you’re securing a long-term processing solution that evolves alongside your product development roadmap.
Mark Costello has been a trusted name in waste management for decades, delivering reliable and effective solutions that businesses count on.
Using the latest technology, We ensures that waste management systems are efficient and up to industry standards, from food digesters to compactors.
At Mark Costello,we provides tailored waste management solutions that fit each business’s unique needs, ensuring a smooth integration into existing operations.
Mark Costello is dedicated to helping businesses achieve their sustainability goals by turning waste into valuable resources, supporting a greener future.
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You’ll want to include details about your product’s material characteristics such as particle hardness, moisture content, target particle size, throughput volume, and whether the product is heat- or pressure-sensitive. Let us know if your process requires containment, dust collection, or CIP systems so we can tailor the solution accordingly.
All of our equipment for the pharmaceutical industry is constructed with GMP-ready materials like 316L stainless steel, sanitary welds, and hygienic seals. We also supply IQ, OQ, and PQ documentation, as well as FAT and SAT services to assist with your validation process.
Yes, we design systems specifically for high-potency active ingredients (HPAPIs) with containment features such as glove box compatibility, HEPA filtration, and nitrogen inerting. We prioritize safety for both product and operator throughout the process.
We offer modular, scalable equipment that begins at the lab bench and can grow with you into commercial production. This helps maintain continuity in particle size distribution and process parameters, reducing the need for revalidation later.
Yes, many of our size reduction systems can be outfitted with CIP features, which are crucial for maintaining sterile conditions and reducing downtime between batches. CIP support is especially important in multiproduct facilities or when handling allergenic substances.
Typical lead times range from 10 to 16 weeks depending on complexity and customization needs. For lab-scale or standard units, turnaround may be faster. We recommend initiating your quote early to stay aligned with project timelines and regulatory deadlines.