

Most medical waste generators in California rely on third-party haulers—but that model is starting to show its flaws. Missed pickups, overfilled storage bins, and rising transport costs are leading many providers to reconsider. Enter on-site autoclave systems, compact and efficient devices that sterilize waste right where it’s generated. They eliminate the wait, reduce handling risks, and give you full control of compliance. Ever had to delay a patient procedure because your biohazard bin was full? Or worried about weekend waste piling up?
With autoclaving, regulated waste is exposed to saturated steam at high temperatures—usually between 250°F and 270°F—for 30 to 60 minutes. That kills over 99.9999% of infectious organisms. After that, much of the treated material can be safely discarded with normal trash, assuming local disposal rules allow it. Did you know autoclaving reduces biohazard volume by as much as 90%? That’s not just convenient—it’s environmentally responsible.
At The Mark-Costello Co., we’ve helped over 600 facilities across the U.S. and 23 countries install on-site sterilization systems that meet state and federal compliance. Most of our clients ask the same thing: Can my staff operate it safely? Will I need extra space or ventilation? The answer is: these units are built for real-world conditions. Whether you're in a 4-chair dental office or a large outpatient surgery center, there’s a model designed to fit your workflow and waste output. What’s more, our systems come with maintenance and validation tools so you can always prove your compliance when the inspector walks in.

Mark Costello has been a trusted name in waste management for decades, delivering reliable and effective solutions that businesses count on.
Using the latest technology, We ensures that waste management systems are efficient and up to industry standards, from food digesters to compactors.
At Mark Costello,we provides tailored waste management solutions that fit each business’s unique needs, ensuring a smooth integration into existing operations.
Mark Costello is dedicated to helping businesses achieve their sustainability goals by turning waste into valuable resources, supporting a greener future.

Send us a message with your questions or concerns and our team member will contact you. We’d love to hear from you.
Dear Mr. Markle,
I have been working in the Plant Operations of Hospitals for the past 20 years. During that time I have had the responsibility of maintaining various autoclaves for the treatment of biohazardous medical waste.
When I came to Doctors Medical Center a year and a half ago I found myself in charge of maintaining a Mark-Costello Co. autoclave that was nearly eight years old. After my past experience of trying to keep a high vacuum system with consistent problems in operation, I find maintaining the Mark-Costello gravity fed autoclave a pleasure, as there is seldom a malfunction. I attribute this to the fact they have kept the design simple with no need for highly technical maintenance and high dollar repair parts.
As a point of information, the Model we operate is a AS 512 equipped with a unique “pull out drawer” making it easy for the Housekeeping Staff to load. This unit has a capacity of approximately 750 lbs. per cycle.
We expect to keep our Mark-Costello autoclave in operation for another 8 years or longer !
Dear Mr. Markle:
San Ramon regional Medical Center has owned and operated a Model AS46 Mark-Costello Medical Waste Sterilizer for the past eight years. We are pleased with performance of this equipment and have had a fine working relationship with the Mark-Costello Company. The system continues to function well and allows our facility to avoid the liability and high cost of packaging and hauling untreated infectious waste.
We Anticipate several more years of operation from this waste treatment system
Saludos,
La presente es para agradecer sus servicios a nuestra compañia. Su equipo de trabajo ha sido muy atento y diligente en las gestiones realizadas. Estamos muy complacidos con el equipo, el precio y la calidad de sus servicios.
Esperamos seguir contando con una excelente relacion de negocios en un futuro muy cercano.
Greetings,
This letter is to thank you for your services to our company. Your teamwork has been very attentive and diligent in the way it has been carried out. We are very pleased with the teamwork, the price and the quality of your services.
We expect to continue an excellent business relationship with you in the near future.
To whom it may concern,
Pleased with the equipment
We are quite pleased with our Mark-Costello sterilizer. The sterilizer has been working fine for many years. We recently purchased additional equipment from them, and are impressed with their response time and friendly service. We hope to continue a great working relationship with Mark-Costello in the future for additional pieces of equipment.
“It’s been a great relationship with The Mark-Costello Company; they are very dependable to all of our waste handling requirements and have made us aware of the importance of recycling and the upcoming waste handling issues in the future.”
“We have been very pleased with the performance and the cost savings that the trash compactors from The Mark-Costello Company have provided to our school district.”
My name is David E. and I am responsible for a Mark Costello Co. Auto-Clave, at an inflight Kitchen out here in Kona Hawaii, that is overseen by the USDA / Custom and Borders, federal inspectors. (as you can imagine that is a challenge in its self).
The products that Mark Costello Co. is producing are of good quality. The auto – clave that I am responsible for works 24/7, with very few break downs. This is the only unit available in Kona, making daily operation is critical.
It is nice to know that when I call for tech support and parts, the courteous staff always responds promptly. Being out here in the middle of the pacific, that is crucial to our operation.
I would highly recommend Mark Costello Co.
In California, medical waste includes biohazardous, pathological, pharmaceutical, and trace chemotherapy waste not regulated by the federal Resource Conservation and Recovery Act (RCRA). This encompasses items like contaminated sharps, blood-soaked bandages, surgical instruments, and certain pharmaceutical residues. These materials pose potential risks to human health and the environment due to their infectious, hazardous, or pharmaceutical nature.
Medical waste must be stored in rigid, leak-proof containers clearly labeled with the biohazard symbol. Sharps waste should be disposed of in FDA-approved sharps containers. Storage areas must be secured to prevent unauthorized access. Additionally, biohazardous or sharps waste should not be stored above 0°C (32°F) at any onsite location for more than seven days without obtaining prior written approval from the enforcement agency.
California mandates that all medical waste undergo treatment before disposal. Approved methods include autoclaving (steam sterilization), incineration, and certain alternative technologies that have received approval from the California Department of Public Health (CDPH). These methods are designed to render the waste non-infectious and safe for disposal.
Yes, medical waste transporters must comply with both state and federal regulations. In California, the Medical Waste Management Act (MWMA) governs the transportation of medical waste, requiring proper documentation and adherence to safety standards. Additionally, the U.S. Department of Transportation has specific regulations for transporting medical waste on public roads and highways.
Yes, all medical waste generators in California are required to register with their local enforcement agency, which is typically the county’s Environmental Health Department. This registration ensures compliance with the MWMA and facilitates inspections to verify adherence to medical waste management standards.
Improper disposal of medical waste in California can result in significant penalties, including fines and potential legal action. For instance, Kaiser Permanente agreed to pay $49 million to settle allegations of illegally dumping private medical records and medical waste, highlighting the serious consequences of non-compliance.
